Cosmetics industry speaks a lot about active ingredients and how to deliver their benefits to the skin. Neurocosmetic functional ingredients are different, they not only have a direct action on the skin, but also communicate with the nervous system and eventually can affect the brain’s responses to topical and oral treatments.

Indeed, many emotions as stress and happiness are felt at the skin level creating different skin reactions as paling, blushing or radiance. The connection mechanisms between the skin and the brain should be useful in choosing functional ingredients able to interact with both systems, obtaining specific results. There is a number of natural ingredients that can serve this dual function of acting on the nervous system to deliver benefits of the improved “well-being” whilst maintaining its topical use.

Neurocosmetic functional ingredients can act by following two main mechanisms. The first acts directly on the cutaneous nervous fiber endings, as modulators of the neurotransmitter release, an example are the botulinum-like peptides that encourage facial musculature relaxation to obtain wrinkle-smoothing. Or they can act modulating non-nervous cells’ functions as agonist/antagonist molecules of the neuropeptide receptors or neurotransmitter effects modulators.

In conclusion, neurocosmetic functional ingredients, by targeting the interactions between the skin and the nervous system, can play a significant role in skin balance, conferring it a soothing effect, with the result of a smoother, more radiant, healthier, and less wrinkled skin contributing to the decreasing of the inflammatory response.

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Neurocosmetic functional ingredients can be used in combination with other active ingredients, formulated in different cosmetic forms to target every consumer’s skin type and age. However, in the market, these types of ingredients are mainly employed in anti-age and sensitive skin formulations or to combat skin stress.

Monk’s pepper, a large shrub that grows in Mediterranean regions and Asia. Its berries contain phyto-endorphins, that bind to the opioid receptor causing an analgesic effect and a sense of well-being, it stimulates the activities of both, β-endorphin, the body’s own happy molecule and DHEA. This neurocosmetic functional ingredient helps to increases skin hydration, firmness, density and elasticity while stimulating collagen production.

Anandamide: Since its discovery in 1992 anandamide (w word coming from Sanskrit: ānanda meaning joy or bliss) has been widely studied for its effects on pain relief, sleep quality, and lately cell regeneration. Dr. Mauro Maccarrone led fascinating research and published a paper on the effects of anandamide on regulating the differentiation of keratinocytes, responsible for the outermost layer of our skin. Naturally present in multiple plants it made its name through a famous research that has found its traces in chocolate. This natural active ingredient interacts with ECS and accesses our nervous system in a similar manner to CBD making it a perfect candidate for a neurocosmetic application.

Tephrosia purpurea. Its a common wasteland weed from Inmdia and Sri lanka and has been use as an ethnomedicine to treat a number of conditions. Explored as a neurocsosmetic it can help stimulate the production of betaendorphiones, whilst maintaining properties of

Swiss Stone Pine, also know as the King of the Alpes provides a multitude of uses. The extraction process allows to produce an active ingredient that calms the skins sensitivityinlcuding reducing redness Protection of collagen and antiinflammatory properties position this ingredient as a great compliment to the growing line of neuroactive ingredients ,

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